Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 17/20 | 0.57 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.47 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL387771 | 0.91 | GPR119 (0.68) | GPR119CYP4F2CYP4A11 | |
| SCHEMBL387578 | 0.91 | GPR119 (0.68) | GPR119CYP4F2CYP4A11 | |
| SCHEMBL387579 | 0.91 | GPR119 (0.68) | GPR119CYP4F2CYP4A11 | |
| SCHEMBL2883381 | 0.90 | GPR119 (0.44) | GPR119 | |
| Trifluoroacetic Acid SCHEMBL386580 | 0.86 | GPR119 (0.62) | GPR119CYP4F2CYP4A11 | |
| SCHEMBL3986034 | 0.85 | GPR119 (0.52) | GPR119CYP4F2CYP4A11 | |
| SCHEMBL14191032 | 0.84 | GPR119 (0.68) | GPR119CYP4F2CYP4A11 | |
| SCHEMBL388999 | 0.80 | GPR119 (0.53) | GPR119 | |
| SCHEMBL389001 | 0.78 | GPR119 (0.58) | GPR119CYP4F2CYP4A11 | |
| SCHEMBL388632 | 0.78 | GPR119 (0.69) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2010512334-A | — | — | 2010-04-22 | — | — | JP | claimed |
| EP-2094683-A2 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | SmithKline Beecham Corporation (US) | 2009-09-02 | — | — | EP | claimed |
| WO-2008070692-A2 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-06-12 | — | — | WO | claimed |
| EP-2094683-A2 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | SmithKline Beecham Corporation (US) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008070692-A2 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-06-12 | — | — | WO | disclosed |