Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27854105 | 0.88 | BACE1 (0.33) | ALDH1A1BACE1BACE2 | |
| SCHEMBL27854049 | 0.75 | BACE1 (0.32) | BACE1BACE2 | |
| SCHEMBL27854022 | 0.72 | BACE1 (0.34) | BACE1BACE2 | |
| SCHEMBL363947 | 0.72 | PGR (0.32) | ALDH1A1BACE1BACE2 | |
| SCHEMBL361625 | 0.69 | HCAR2 (0.36) | ALDH1A1BACE1BACE2 | |
| SCHEMBL15643307 | 0.68 | BACE1 (0.36) | BACE1BACE2 | |
| SCHEMBL27854106 | 0.68 | BACE1 (0.34) | BACE1BACE2 | |
| SCHEMBL27886993 | 0.68 | BACE1 (0.34) | BACE1BACE2 | |
| SCHEMBL17673207 | 0.65 | BACE1 (0.40) | ALDH1A1BACE1BACE2 | |
| SCHEMBL361069 | 0.63 | BACE1 (0.31) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102666507-A | Oxazine derivatives and their use in the treatment of neurological disorders | NOVARTIS AG | 2012-09-12 | — | — | CN | disclosed |
| CN-102471293-A | Oxazine derivatives and their use as BACE inhibitors for the treatment of neurological disorders | NOVARTIS AG | 2012-05-23 | — | — | CN | disclosed |