Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 12/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 4/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 7/20 | 0.43 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.38 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.38 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.38 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28795236 | 0.98 | CRBN (0.51) | CRBNBTKARDDB1MAP4K1 | |
| SCHEMBL28795225 | 0.95 | CRBN (0.53) | CRBNBTKARDDB1IKZF1 | |
| SCHEMBL28795307 | 0.94 | CRBN (0.51) | CRBNBTKARDDB1MAP4K1 | |
| SCHEMBL28795226 | 0.94 | CRBN (0.52) | CRBNBTKARDDB1MAP4K1 | |
| SCHEMBL28795444 | 0.93 | CRBN (0.52) | CRBNBTKARDDB1MAP4K1 | |
| SCHEMBL28795151 | 0.90 | CRBN (0.57) | CRBNBTKARDDB1IKZF1 | |
| SCHEMBL29803123 | 0.89 | CRBN (0.46) | CRBNBTKARDDB1MAP4K1 | |
| SCHEMBL28945672 | 0.89 | CRBN (0.46) | CRBNBTKARDDB1MAP4K1 | |
| SCHEMBL28795113 | 0.89 | CRBN (0.56) | CRBNBTKARDDB1IKZF1 | |
| SCHEMBL29803017 | 0.89 | CRBN (0.56) | CRBNBTKARDDB1IKZF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114805303-A | Molecule with double functions of degrading EGFR (epidermal growth factor receptor), composition and pharmaceutical application thereof | 海思科医药集团股份有限公司 | 2022-07-29 | — | — | CN | disclosed |