Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 14/20 | 0.56 |
| ▸ | AR | P10275 | 3/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 8/20 | 0.47 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | IL1B | P01584 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29803017 | 1.00 | CRBN (0.56) | CRBNARDDB1BRD9BTK | |
| SCHEMBL28795151 | 0.99 | CRBN (0.57) | CRBNARDDB1BRD9BTK | |
| SCHEMBL28795226 | 0.95 | CRBN (0.52) | CRBNARDDB1BTKIKZF1 | |
| SCHEMBL28795307 | 0.95 | CRBN (0.51) | CRBNARDDB1BTKIKZF1 | |
| SCHEMBL28795225 | 0.94 | CRBN (0.53) | CRBNARDDB1BRD9BTK | |
| SCHEMBL28795213 | 0.94 | CRBN (0.49) | CRBNARDDB1BRD9BTK | |
| SCHEMBL28795285 | 0.93 | CRBN (0.50) | CRBNARDDB1BRD9BTK | |
| SCHEMBL28795224 | 0.92 | CDK9 (0.51) | CRBNARDDB1BRD9BTK | |
| SCHEMBL28795197 | 0.90 | CRBN (0.47) | CRBNARDDB1BRD9BTK | |
| SCHEMBL31458558 | 0.89 | CRBN (0.54) | CRBNARDDB1BRD9BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114805303-A | Molecule with double functions of degrading EGFR (epidermal growth factor receptor), composition and pharmaceutical application thereof | 海思科医药集团股份有限公司 | 2022-07-29 | — | — | CN | disclosed |