Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 12/20 | 0.54 |
| ▸ | HRH1 | P35367 | 12/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27945276 | 0.85 | HRH2 (0.51) | HRH2HRH1OPRK1CYP1A2MAPK1 | |
| SCHEMBL27839020 | 0.83 | HRH2 (0.51) | HRH2HRH1OPRK1CYP1A2MAPK1 | |
| SCHEMBL27856827 | 0.82 | HRH2 (0.47) | HRH2HRH1OPRK1CYP1A2MAPK1 | |
| SCHEMBL27926403 | 0.80 | HRH2 (0.48) | HRH2HRH1OPRK1CYP1A2MAPK1 | |
| SCHEMBL17152649 | 0.77 | PIK3CD (0.58) | HRH2HRH1SLC7A5DPP4DPP8 | |
| SCHEMBL20413344 | 0.77 | HRH2 (0.47) | HRH2HRH1SLC7A5DPP4DPP8 | |
| SCHEMBL20413342 | 0.77 | DPP4 (0.45) | HRH2HRH1CYP1A2SLC7A5DPP4 | |
| SCHEMBL13995145 | 0.77 | DPP4 (0.45) | HRH2HRH1CYP1A2SLC7A5DPP4 | |
| SCHEMBL27945272 | 0.76 | OPRK1 (0.59) | HRH2HRH1OPRK1 | |
| Hydrochloric Acid SCHEMBL10861194 | 0.76 | HRH2 (0.46) | HRH2HRH1SLC7A5DPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102369197-B | 6-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-phenyl-pyrimidines used as ADP receptor antagonists | ACTELION PHARMACEUTICALS LTD | 2013-11-06 | — | — | CN | disclosed |
| CN-102369197-A | 6-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-phenyl-pyrimidines used as adp receptor antagonists | ACTELION PHARMACEUTICALS LTD | 2012-03-07 | — | — | CN | disclosed |