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SCHEMBL28795497

SCHEMBL28795497

Cc1cc(C)c(CNC(=O)c2cc(-c3cn(C)c(=O)c4[nH]ccc34)cc3c2cnn3C2CCCC2)c(=O)[nH]1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ EZH2 Q15910 20/20 1.00
▸ BRD4 O60885 6/20 0.81
▸ BRD2 P25440 1/20 0.67
▸ BRD3 Q15059 1/20 0.67
▸ BRDT Q58F21 1/20 0.67
▸ EZH1 Q92800 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30615188 1.00 EZH2 (1.00) EZH2BRD4BRD2BRD3BRDT
SCHEMBL28795470 0.89 EZH2 (1.00) EZH2BRD4BRD2BRD3BRDT
SCHEMBL28795561 0.85 EZH2 (1.00) EZH2BRD4BRD2BRD3BRDT
SCHEMBL28795531 0.83 EZH2 (1.00) EZH2BRD4BRD2BRD3BRDT
SCHEMBL2591592 0.83 EZH2 (0.70) EZH2BRD4EZH1
SCHEMBL28795486 0.81 EZH2 (1.00) EZH2BRD4BRD2BRD3BRDT
SCHEMBL2592259 0.81 EZH2 (0.67) EZH2EZH1
SCHEMBL12498209 0.80 EZH2 (0.67) EZH2BRD4EZH1
SCHEMBL12180805 0.80 EZH2 (0.67) EZH2EZH1
SCHEMBL12180727 0.80 EZH2 (0.70) EZH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114805350-B Benzo heterocycle-pyridone derivative, and preparation method and application thereof 四川大学华西医院 2023-10-20 — — CN disclosed
CN-114805350-A Benzo-heterocycle-pyridone derivatives and preparation method and application thereof 四川大学华西医院 2022-07-29 — — CN disclosed
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