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SCHEMBL28795486

SCHEMBL28795486

CCC(CC)n1ccc2c(C(=O)NCc3c(C)cc(C)[nH]c3=O)cc(-c3cn(C)c(=O)c4[nH]ccc34)cc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ EZH2 Q15910 20/20 1.00
▸ BRD4 O60885 6/20 1.00
▸ BRD2 P25440 1/20 0.88
▸ BRD3 Q15059 1/20 0.88
▸ BRDT Q58F21 1/20 0.88
▸ EZH1 Q92800 1/20 0.88

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28795592 0.93 EZH2 (1.00) EZH2BRD4BRD2BRD3BRDT
SCHEMBL28795581 0.91 EZH2 (1.00) EZH2BRD4BRD2BRD3BRDT
SCHEMBL28795589 0.85 EZH2 (1.00) EZH2BRD4BRD2BRD3BRDT
SCHEMBL28795470 0.84 EZH2 (1.00) EZH2BRD4BRD2BRD3BRDT
SCHEMBL28795561 0.82 EZH2 (1.00) EZH2BRD4BRD2BRD3BRDT
SCHEMBL30615188 0.81 EZH2 (1.00) EZH2BRD4BRD2BRD3BRDT
SCHEMBL28795497 0.81 EZH2 (1.00) EZH2BRD4BRD2BRD3BRDT
SCHEMBL16197843 0.78 EZH2 (0.73) EZH2BRD4BRD2BRD3BRDT
SCHEMBL28795531 0.78 EZH2 (1.00) EZH2BRD4BRD2BRD3BRDT
SCHEMBL23030221 0.77 EZH2 (0.62) EZH2BRD4BRD2BRD3BRDT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114805350-B Benzo heterocycle-pyridone derivative, and preparation method and application thereof 四川大学华西医院 2023-10-20 — — CN disclosed
CN-114805350-A Benzo-heterocycle-pyridone derivatives and preparation method and application thereof 四川大学华西医院 2022-07-29 — — CN disclosed
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