Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.57 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.57 |
| ▸ | BACE1 | P56817 | 2/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19075229 | 0.88 | EPHX2 (0.55) | EPHX2PRMT6BACE1GRM5MKNK1 | |
| SCHEMBL10202792 | 0.86 | EPHX2 (0.52) | EPHX2PRMT6BACE1GRM5MKNK1 | |
| SCHEMBL10268304 | 0.83 | EPHX2 (0.52) | EPHX2PRMT6BACE1GRM5MKNK1 | |
| SCHEMBL24700847 | 0.83 | EPHX2 (0.62) | EPHX2PRMT6BACE1GRM5MKNK1 | |
| SCHEMBL16215590 | 0.82 | EPHX2 (0.51) | EPHX2PRMT6BACE1GRM5MKNK1 | |
| SCHEMBL10172770 | 0.82 | CHRNB2 (0.48) | CYP2A6CYP1A2 | |
| SCHEMBL3431577 | 0.80 | NR4A2 (0.49) | EPHX2PRMT6BACE1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6518983 | 0.80 | NR4A2 (0.48) | EPHX2PRMT6BACE1ALDH1A1 | |
| SCHEMBL4403154 | 0.80 | EPHX2 (0.62) | EPHX2PRMT6BACE1MKNK1MKNK2 | |
| SCHEMBL3415674 | 0.78 | MAP4K4 (0.53) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102036987-A | Polysubstituted derivatives of 2-heteroaryl-6-phenylimidazo [1,2-a ] pyridines, process for their preparation and their therapeutic use | SANOFI AVENTIS | 2011-04-27 | — | — | CN | disclosed |