Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 17/20 | 1.00 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | AGPAT2 | O15120 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10036320 | 0.85 | ROCK2 (1.00) | ROCK2ROCK1CYP3A4 | |
| SCHEMBL8320434 | 0.83 | ROCK1 (0.87) | ROCK2ROCK1CYP3A4AGPAT2 | |
| SCHEMBL2880011 | 0.83 | ROCK1 (1.00) | ROCK2ROCK1CYP3A4AGPAT2 | |
| SCHEMBL2876683 | 0.83 | ROCK2 (0.76) | ROCK2ROCK1CYP3A4 | |
| SCHEMBL2880092 | 0.81 | ROCK2 (0.73) | ROCK2ROCK1CYP3A4 | |
| SCHEMBL10036322 | 0.81 | ROCK2 (0.91) | ROCK2ROCK1CYP3A4AGPAT2 | |
| SCHEMBL2880069 | 0.79 | ROCK2 (1.00) | ROCK2ROCK1CYP3A4 | |
| SCHEMBL5258702 | 0.79 | ROCK2 (0.86) | ROCK2ROCK1CYP3A4 | |
| SCHEMBL2881306 | 0.77 | ROCK2 (0.67) | ROCK2ROCK1CYP3A4AGPAT2 | |
| SCHEMBL8328328 | 0.77 | ROCK1 (0.85) | ROCK2ROCK1CYP3A4AGPAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7737153-B2 | Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-06-15 | — | — | US | disclosed |
| US-7737153-B2 | Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-06-15 | — | — | US | disclosed |
| US-7737153-B2 | Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-06-15 | — | — | US | disclosed |
| US-20060241127-A1 | Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors | BAYER HEALTHCARE AG (DE) | 2006-10-26 | — | — | US | disclosed |
| EP-1562935-B1 | HETEROARYLOXY-SUBSTITUTED PHENYLAMINOPYRIMIDINES AS RHO-KINASE INHIBITORS | BAYER HEALTHCARE AG (DE) | 2006-09-06 | — | — | EP | disclosed |
| WO-2004039796-A1 | HETEROARYLOXY-SUBSTITUTED PHENYLAMINOPYRIMIDINES AS RHO-KINASE INHIBITORS | BAYER HEALTHCARE AG (DE) | 2004-05-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241127-A1 | Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors | ROCK1, ROCK2, RHOA | ROCK2 2/4885ROCK1 1/4885CYP3A4 2229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.