SCHEMBL28797807

SCHEMBL28797807

CCS(=O)(=O)c1ccc([C@H](CO)NC(=O)c2cc3cc(Cc4ccc(Cl)cc4C(F)(F)F)n(CCO)c3cc2F)cc1

nearest known ligand 0.72

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RORC P51449 15/20 0.72
PHGDH O43175 5/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28797810 1.00 RORC (0.72) RORCPHGDH
SCHEMBL20635529 0.95 RORC (0.80) RORCPHGDH
SCHEMBL21877839 0.95 RORC (0.80) RORCPHGDH
SCHEMBL28797815 0.93 RORC (0.62) RORCPHGDH
SCHEMBL28797812 0.93 RORC (0.62) RORCPHGDH
SCHEMBL29654144 0.93 RORC (0.62) RORCPHGDH
SCHEMBL20635530 0.88 RORC (0.62) RORC
SCHEMBL21877834 0.88 RORC (0.62) RORC
SCHEMBL29654048 0.87 RORC (0.60) RORCPHGDH
SCHEMBL28797821 0.87 RORC (0.60) RORCPHGDH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109485595-B Hydrophilic group substituted indole formamide derivative, preparation method and medical application thereof 江苏恒瑞医药股份有限公司 2022-05-27 CN disclosed