Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.68 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.51 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10595718 | 0.87 | ATM (0.71) | ATMHPGDMAPTRAB9AEPHX2 | |
| SCHEMBL7620949 | 0.82 | ATM (0.69) | ATMHPGDMAPTRAB9AEPHX2 | |
| SCHEMBL7614096 | 0.82 | ATM (0.69) | ATMHPGDMAPTRAB9AEPHX2 | |
| SCHEMBL27874520 | 0.82 | EPHX1 (0.58) | ATMHPGDMAPTRAB9AEPHX1 | |
| SCHEMBL10800831 | 0.81 | KMT2A (0.55) | ATMMAPTRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL11599130 | 0.81 | ATM (1.00) | ATMHPGDMAPTRAB9AEPHX2 | |
| SCHEMBL7613507 | 0.80 | ATM (0.67) | ATMHPGDMAPTRAB9AEPHX2 | |
| SCHEMBL9547525 | 0.79 | ATM (0.66) | ATMHPGDMAPTRAB9AEPHX2 | |
| SCHEMBL28728490 | 0.77 | ATM (0.62) | ATMHPGDMAPTRAB9AEPHX2 | |
| Fenuron SCHEMBL10820802 | 0.75 | ATM (0.64) | ATMHPGDMAPTRAB9AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102471339-A | Pyrrolopyridine inhibitors of kinases | ABBOTT LAB | 2012-05-23 | — | — | CN | claimed |
| CN-102471339-A | Pyrrolopyridine inhibitors of kinases | ABBOTT LAB | 2012-05-23 | — | — | CN | disclosed |