Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 | P30411 | 6/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | EIF4EBP1 | Q13541 | 6/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.30 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.30 |
| ▸ | ATP1A3 | P13637 | 1/20 | 0.30 |
| ▸ | ATP1B2 | P14415 | 1/20 | 0.30 |
| ▸ | ATP4A | P20648 | 1/20 | 0.30 |
| ▸ | ATP1A2 | P50993 | 1/20 | 0.30 |
| ▸ | ATP4B | P51164 | 1/20 | 0.30 |
| ▸ | ATP1B3 | P54709 | 1/20 | 0.30 |
| ▸ | FXYD2 | P54710 | 1/20 | 0.30 |
| ▸ | ATP1A4 | Q13733 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2868604 | 0.93 | BDKRB2 (0.76) | BDKRB2CYP3A4CYP2C19EIF4EBP1RORC | |
| SCHEMBL2875517 | 0.88 | BDKRB2 (0.61) | BDKRB2CYP3A4CYP2C19PTGDR2NR1H4 | |
| SCHEMBL2872135 | 0.88 | BDKRB2 (0.52) | BDKRB2CYP3A4CYP2C19SYKEIF4EBP1 | |
| SCHEMBL1564395 | 0.87 | BDKRB2 (0.87) | BDKRB2CYP3A4CYP2C19RORC | |
| SCHEMBL2871993 | 0.81 | BDKRB2 (0.48) | BDKRB2CYP3A4CYP2C19PTGDR2NR1H4 | |
| SCHEMBL2868602 | 0.80 | BDKRB2 (1.00) | BDKRB2CYP3A4CYP2C19RORC | |
| SCHEMBL13093047 | 0.80 | BDKRB2 (0.90) | BDKRB2CYP3A4CYP2C19RORC | |
| SCHEMBL13146271 | 0.80 | BDKRB2 (0.80) | BDKRB2CYP3A4CYP2C19RORC | |
| SCHEMBL12711960 | 0.80 | BDKRB2 (0.88) | BDKRB2CYP3A4CYP2C19RORC | |
| SCHEMBL2874958 | 0.79 | BDKRB2 (0.50) | BDKRB2CYP3A4CYP2C19EIF4EBP1RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2144897-B1 | 8-OXY-QUINOLINE DERIVATIVES AS BRADYKININ B2 RECEPTOR MODULATORS | JERINI AG (DE) | 2010-10-20 | — | — | EP | claimed |