Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | FPR1 | P21462 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2880162 | 1.00 | SMN1; SMN2 (0.41) | SMN1; SMN2TDP1ALDH1A1MAPTHTT | |
| SCHEMBL213919 | 0.92 | SMN1; SMN2 (0.42) | SMN1; SMN2TDP1ALDH1A1MAPTHTT | |
| SCHEMBL213917 | 0.92 | SMN1; SMN2 (0.42) | SMN1; SMN2TDP1ALDH1A1MAPTHTT | |
| SCHEMBL213918 | 0.92 | SMN1; SMN2 (0.42) | SMN1; SMN2TDP1ALDH1A1MAPTHTT | |
| SCHEMBL210513 | 0.84 | HTT (0.35) | SMN1; SMN2HTTMEN1KMT2ALMNA | |
| SCHEMBL210514 | 0.84 | HTT (0.35) | SMN1; SMN2HTTMEN1KMT2ALMNA | |
| SCHEMBL210515 | 0.84 | HTT (0.35) | SMN1; SMN2HTTMEN1KMT2ALMNA | |
| SCHEMBL211266 | 0.82 | CTSK (0.34) | ALDH1A1HTTMEN1KMT2ATSHR | |
| SCHEMBL212993 | 0.80 | GRM5 (0.32) | SMN1; SMN2HTTMEN1KMT2ATSHR | |
| SCHEMBL212992 | 0.80 | GRM5 (0.32) | SMN1; SMN2HTTMEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195328-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Incorporated (US) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009023193-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2009-02-19 | — | — | WO | disclosed |