Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 16/20 | 0.53 |
| ▸ | IKZF3 | Q9UKT9 | 15/20 | 0.53 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.43 |
| ▸ | TNF | P01375 | 3/20 | 0.41 |
| ▸ | IL1B | P01584 | 3/20 | 0.41 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27899070 | 0.91 | CRBN (0.44) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL27881791 | 0.90 | CRBN (0.51) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL27899081 | 0.89 | CRBN (0.44) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL27899082 | 0.89 | CRBN (0.48) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL27899016 | 0.89 | CRBN (0.48) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL27899007 | 0.87 | HTT (0.40) | CRBNIKZF3LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL2249876 | 0.85 | CRBN (0.52) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL27899276 | 0.83 | HTT (0.38) | CRBNIKZF3LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL27899074 | 0.82 | SLC1A5 (0.40) | SMN1; SMN2HTT | |
| SCHEMBL27899013 | 0.81 | SMN1; SMN2 (0.41) | CRBNIKZF3LMNASMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102822165-A | Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same | CELGENE CORP | 2012-12-12 | — | — | CN | disclosed |