Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.38 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.38 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23580456 | 0.88 | HSD17B10 (0.46) | HSD17B10ALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL27902943 | 0.83 | HSD17B10 (0.41) | HSD17B10ALDH1A1ALOX5APFEN1SMARCA2 | |
| SCHEMBL15250326 | 0.79 | HSD17B10 (0.46) | HSD17B10ALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL28450783 | 0.77 | HSD17B10 (0.48) | HSD17B10ALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL28897414 | 0.77 | HSD17B10 (0.48) | HSD17B10ALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL2312693 | 0.76 | ESR2 (0.40) | HSD17B10ALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL23579744 | 0.76 | HPRT1 (0.48) | HSD17B10ALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL21199977 | 0.75 | ALOX5AP (0.42) | HSD17B10ALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL16615862 | 0.74 | ALDH1A1 (0.62) | HSD17B10ALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL30594664 | 0.74 | ALDH1A1 (0.62) | HSD17B10ALDH1A1PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110446704-B | Process for the preparation of sulfonamide-structured kinase inhibitors | 奥赖恩公司 | 2022-07-05 | — | — | CN | claimed |
| CN-115124470-A | Process for the preparation of sulfonamide-structured kinase inhibitors | 奥赖恩公司 | 2022-09-30 | — | — | CN | disclosed |
| CN-110446704-B | Process for the preparation of sulfonamide-structured kinase inhibitors | 奥赖恩公司 | 2022-07-05 | — | — | CN | disclosed |