Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | HTR6 | P50406 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL288153 | 0.90 | NPC1 (0.62) | MEN1KMT2ANPC1SMN1; SMN2HPGD | |
| SCHEMBL2877335 | 0.85 | MAPT (0.54) | MEN1KMT2AHTR6TP53MAPT | |
| SCHEMBL10066942 | 0.83 | TP53 (0.57) | MEN1KMT2ANPC1TP53SMN1; SMN2 | |
| SCHEMBL2882066 | 0.81 | HTR6 (0.47) | MEN1KMT2ANPC1HTR6TP53 | |
| SCHEMBL3182062 | 0.81 | TP53 (0.55) | MEN1KMT2ANPC1TP53SMN1; SMN2 | |
| SCHEMBL9464771 | 0.81 | TP53 (0.49) | MEN1KMT2ATP53SMN1; SMN2HPGD | |
| SCHEMBL18363030 | 0.80 | TP53 (0.62) | MEN1KMT2AHTR6TP53POLB | |
| SCHEMBL13531815 | 0.80 | MEN1 (0.66) | MEN1KMT2ATP53SMN1; SMN2MAPT | |
| SCHEMBL15101544 | 0.79 | HPGD (0.64) | MEN1KMT2ANPC1TP53SMN1; SMN2 | |
| SCHEMBL10022381 | 0.79 | TP53 (0.65) | MEN1KMT2ATP53SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100234422-A1 | Sulfonylated Heterocycles Useful for Modulation of the Progesterone Receptor | WYETH LLC (US) | 2010-09-16 | — | — | US | disclosed |
| US-7750038-B2 | Sulfonylated heterocycles useful for modulation of the progesterone receptor | WYETH LLC (US) | 2010-07-06 | — | — | US | disclosed |
| EP-2121657-A1 | SULFONYLATED HETEROCYCLES USEFUL FOR MODULATION OF THE PROGESTERONE RECEPTOR | Wyeth (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008109056-A1 | SULFONYLATED HETEROCYCLES USEFUL FOR MODULATION OF THE PROGESTERONE RECEPTOR | WYETH (US) | 2008-09-12 | — | — | WO | disclosed |
| US-20080221160-A1 | SULFONYLATED HETEROCYCLES USEFUL FOR MODULATION OF THE PROGESTERONE RECEPTOR | WYETH (US) | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221160-A1 | SULFONYLATED HETEROCYCLES USEFUL FOR MODULATION OF THE PROGESTERONE RECEPTOR | GNRHR, FSHR, PRLHR | MEN1 490/4885KMT2A 2197/4885NPC1 4498/4885 |
| US-20100234422-A1 | Sulfonylated Heterocycles Useful for Modulation of the Progesterone Receptor | GNRHR, FSHR, PRLHR | MEN1 490/4885KMT2A 2197/4885NPC1 4498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.