SCHEMBL28804281

SCHEMBL28804281

COc1ccc(CSc2ccnc(-c3ccccc3)c2)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 1/20 0.53
HTR7 P34969 1/20 0.53
MAOB P27338 3/20 0.48
APP P05067 2/20 0.47
MAOA P21397 2/20 0.45
NPC1 O15118 4/20 0.45
RAB9A P51151 4/20 0.45
PLAU P00749 1/20 0.44
ALDH1A1 P00352 2/20 0.43
LMNA P02545 1/20 0.43
TGFBR1 P36897 1/20 0.43
OPRK1 P41145 1/20 0.43
TP53 P04637 1/20 0.43
TSHR P16473 1/20 0.43
MEN1 O00255 1/20 0.42
NFKB1 P19838 1/20 0.42
NFKB2 Q00653 1/20 0.42
KMT2A Q03164 1/20 0.42
RELA Q04206 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL192485 0.78 MAOB (0.43) MAOBAPPMAOANPC1RAB9A
SCHEMBL191181 0.78 DYRK1A (0.53) MAOBAPPMAOANPC1RAB9A
SCHEMBL29661774 0.78 MAOB (0.52) MAOBAPPMAOANPC1RAB9A
SCHEMBL190495 0.78 MAOB (0.52) MAOBAPPMAOANPC1RAB9A
SCHEMBL2272164 0.76 APP (0.69) MAOBAPPMAOANPC1RAB9A
SCHEMBL7815567 0.76 MAOB (0.50) HTR1AMAOBAPPMAOANPC1
SCHEMBL7829875 0.75 LOX (0.46) MAOBMAOANPC1RAB9AALDH1A1
SCHEMBL8255854 0.74 APP (0.65) MAOBAPPMAOANPC1RAB9A
SCHEMBL29386644 0.73 CCR1 (0.70) NPC1RAB9APLAUALDH1A1TGFBR1
SCHEMBL12753751 0.73 CCR1 (0.70) NPC1RAB9APLAUALDH1A1TGFBR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114716367-B Method for preparing 4-mercaptopyridine compound by micro-flow field reactor technology 南京工业大学 2024-04-12 CN disclosed
CN-114716367-A Method for preparing 4-mercaptopyridine compound by virtue of micro-flow field reactor technology 南京工业大学 2022-07-08 CN disclosed