Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA2 | P54646 | 11/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.42 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.42 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.42 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.42 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.42 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.42 |
| ▸ | CCR5 | P51681 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1001840 | 0.83 | MCHR1 (0.45) | PRKAA2MCHR1POLBPRKAB2PRKAG1 | |
| SCHEMBL2883960 | 0.80 | MCHR1 (0.55) | PRKAA2PIK3CAMCHR1CCR5DRD2 | |
| SCHEMBL2883957 | 0.80 | MCHR1 (0.55) | PRKAA2PIK3CAMCHR1CCR5DRD2 | |
| SCHEMBL2883696 | 0.79 | MCHR1 (0.52) | PRKAA2MCHR1CCR5DRD2ADRA1A | |
| SCHEMBL2878240 | 0.79 | MCHR1 (0.41) | PRKAA2PIK3CAMCHR1POLBPRKAB2 | |
| SCHEMBL2882785 | 0.79 | PRKAA2 (0.42) | PRKAA2PIK3CAMCHR1DRD2ADRA1A | |
| SCHEMBL12975697 | 0.75 | MCHR1 (0.50) | MCHR1CCR5DRD2ADRA1A | |
| SCHEMBL12975704 | 0.75 | MCHR1 (0.49) | PRKAA2MCHR1POLBDRD2ADRA1A | |
| SCHEMBL2883703 | 0.74 | MCHR1 (0.58) | PRKAA2PIK3CAMCHR1CCR5ALDH1A1 | |
| SCHEMBL2883697 | 0.74 | MCHR1 (0.58) | PRKAA2PIK3CAMCHR1CCR5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100324049-A1 | DIARYL KETIMINE DERIVATIVE HAVING ANTAGONISM AGAINST MELANIN-CONCENTRATING HORMONE RECEPTOR | MSD K.K. (JP) | 2010-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324049-A1 | DIARYL KETIMINE DERIVATIVE HAVING ANTAGONISM AGAINST MELANIN-CONCENTRATING HORMONE RECEPTOR | MC1R, MCHR1, MCHR2 | PRKAA2 3043/4885PIK3CA 3373/4885MCHR1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.