Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA2 | P54646 | 20/20 | 0.79 |
| ▸ | PRKAB2 | O43741 | 16/20 | 0.79 |
| ▸ | PRKAG1 | P54619 | 16/20 | 0.79 |
| ▸ | PRKAA1 | Q13131 | 16/20 | 0.79 |
| ▸ | PRKAG3 | Q9UGI9 | 16/20 | 0.79 |
| ▸ | PRKAG2 | Q9UGJ0 | 16/20 | 0.79 |
| ▸ | PRKAB1 | Q9Y478 | 16/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL517976 | 0.94 | PRKAA2 (0.89) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL10214249 | 0.90 | PRKAA2 (0.82) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL27927338 | 0.90 | PRKAB2 (0.79) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL519244 | 0.89 | PRKAA2 (0.80) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL518066 | 0.89 | PRKAA2 (1.00) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL518939 | 0.88 | PRKAA2 (0.89) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL518470 | 0.88 | PRKAA2 (0.89) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL27927261 | 0.88 | PRKAA2 (0.66) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL518598 | 0.87 | PRKAA2 (0.90) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL518701 | 0.84 | PRKAA2 (1.00) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103201267-A | AMPK-activating heterocyclic compounds and methods of use thereof | RIGEL PHARMACEUTICALS INC | 2013-07-10 | — | — | CN | claimed |