SCHEMBL28808697

SCHEMBL28808697

N#Cc1ccc(CON(OCc2ccc(C#N)cc2)C(=O)C(N)=O)cc1

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 3/20 0.43
GAA P10253 2/20 0.42
LOXL2 Q9Y4K0 1/20 0.42
IDO1 P14902 2/20 0.41
TSHR P16473 1/20 0.41
KCNH2 Q12809 1/20 0.41
PARP15 Q460N3 1/20 0.41
PARP10 Q53GL7 1/20 0.41
PARP2 Q9UGN5 1/20 0.41
NPC1 O15118 3/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
SMPD1 P17405 1/20 0.40
MAPK8 P45983 1/20 0.40
MAOB P27338 2/20 0.40
MMP2 P08253 1/20 0.40
SAE1 Q9UBE0 1/20 0.40
UBA2 Q9UBT2 1/20 0.40
HTT P42858 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28808716 0.79 IDO1 (0.46) RAB9AIDO1NPC1SMN1; SMN2L3MBTL1
SCHEMBL28808708 0.78 PARP10 (0.45) RAB9AIDO1TSHRPARP10NPC1
SCHEMBL28808706 0.76 IDO1 (0.49) RAB9AIDO1PARP10PARP2NPC1
SCHEMBL28808704 0.75 NR4A2 (0.46) RAB9ANPC1SMN1; SMN2L3MBTL1
SCHEMBL114536 0.75 GAA (0.54) RAB9AGAALOXL2IDO1TSHR
SCHEMBL7368271 0.72 MAOB (0.48) RAB9AGAALOXL2KCNH2NPC1
SCHEMBL20497334 0.71 GAA (0.50) RAB9AGAALOXL2IDO1TSHR
SCHEMBL5316276 0.70 GAA (0.49) RAB9AGAALOXL2IDO1TSHR
SCHEMBL21620282 0.70 NPC1 (0.51) RAB9AGAALOXL2IDO1KCNH2
SCHEMBL21616551 0.70 NPC1 (0.51) RAB9AGAALOXL2IDO1KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112079747-B N-benzyloxy substituted symmetrical oxamide compound and preparation method and application thereof 浙江工业大学 2022-08-16 CN disclosed