Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 6/20 | 0.57 |
| ▸ | FEN1 | P39748 | 6/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | KDM1A | O60341 | 2/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6244080 | 0.79 | ALOX5AP (0.46) | ALOX5APFEN1KMT2A | |
| SCHEMBL27940892 | 0.76 | PIP4K2A (0.51) | KDM1AKMT2A | |
| SCHEMBL6237302 | 0.74 | ALOX5AP (0.53) | ALOX5APFEN1 | |
| SCHEMBL4535022 | 0.74 | KDM1A (0.53) | ALOX5APFEN1MCL1KDM1ALIMK1 | |
| SCHEMBL3834597 | 0.74 | ALOX5AP (0.65) | ALOX5APFEN1 | |
| SCHEMBL4667179 | 0.73 | MCL1 (0.61) | ALOX5APFEN1MCL1KDM1ALIMK1 | |
| SCHEMBL15916309 | 0.73 | FEN1 (1.00) | ALOX5APFEN1 | |
| SCHEMBL2040317 | 0.73 | MCL1 (0.64) | ALOX5APFEN1MCL1KDM1ACDK1 | |
| SCHEMBL4533547 | 0.72 | KDM1A (0.60) | ALOX5APFEN1MCL1KDM1ACDK1 | |
| SCHEMBL31645593 | 0.72 | KDM1A (0.60) | ALOX5APFEN1MCL1KDM1ACDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103380117-A | Picolinamide inhibitors of kinases | ABBOTT LAB | 2013-10-30 | — | — | CN | claimed |
| CN-103380117-A | Picolinamide inhibitors of kinases | ABBOTT LAB | 2013-10-30 | — | — | CN | disclosed |