Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.60 |
| ▸ | MCOLN3 | Q8TDD5 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | CA12 | O43570 | 1/20 | 0.60 |
| ▸ | CA2 | P00918 | 1/20 | 0.60 |
| ▸ | CA9 | Q16790 | 1/20 | 0.60 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CKS1B | P61024 | 1/20 | 0.53 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.53 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31645593 | 1.00 | KDM1A (0.60) | KDM1AMCOLN3LMNACA12CA2 | |
| Trifluoromethanesulfonic Acid SCHEMBL29029435 | 0.87 | MCL1 (0.52) | KDM1AMCOLN3LMNACA12CA2 | |
| SCHEMBL7183442 | 0.87 | LMNA (0.64) | KDM1AMCOLN3LMNACA12CA2 | |
| SCHEMBL7183438 | 0.85 | KDM1A (0.58) | KDM1AMCOLN3LMNACA12CA2 | |
| SCHEMBL4699013 | 0.85 | SLC22A12 (0.55) | KDM1AMCL1CKS1BGLO1SKP2 | |
| SCHEMBL4667179 | 0.85 | MCL1 (0.61) | KDM1AMCOLN3LMNACA12CA2 | |
| SCHEMBL29788215 | 0.85 | KEAP1 (0.61) | KDM1AMCOLN3LMNACA12CA2 | |
| SCHEMBL16759968 | 0.85 | KEAP1 (0.61) | KDM1AMCOLN3LMNACA12CA2 | |
| SCHEMBL3141420 | 0.85 | KDM1A (0.55) | KDM1AMCOLN3LMNACA12CA2 | |
| SCHEMBL2040317 | 0.85 | MCL1 (0.64) | KDM1AMCOLN3LMNACA12CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9096565-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2015-08-04 | — | — | US | disclosed |
| US-20090181943-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. (CA) | 2009-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181943-A1 | Inhibitors of Histone Deacetylase | HDAC1, HDAC11, HDAC3 | KDM1A 29/4885MCOLN3 4015/4885LMNA 424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.