Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | ACE | P12821 | 5/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1504141 | 0.82 | SIRT6 (0.34) | ATMITGB3ITGA2BDPP4 | |
| SCHEMBL15110356 | 0.80 | ACE (0.50) | ATMACE | |
| SCHEMBL34461083 | 0.80 | ACE (0.51) | ACE | |
| SCHEMBL28993929 | 0.79 | DPP4 (0.53) | ATMACEDPP4 | |
| SCHEMBL16267210 | 0.78 | ATM (0.63) | ATMACEDPP4 | |
| SCHEMBL15110042 | 0.78 | ATM (0.63) | ATMACEDPP4 | |
| SCHEMBL16267049 | 0.78 | ATM (0.63) | ATMACEDPP4 | |
| SCHEMBL15110041 | 0.78 | ATM (0.63) | ATMACEDPP4 | |
| SCHEMBL15110224 | 0.78 | ATM (0.63) | ATMACEDPP4 | |
| SCHEMBL468718 | 0.77 | ATM (0.45) | ATMACEITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113057959-B | Ketohexokinase (KHK) iRNA compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2024-07-16 | — | — | CN | disclosed |
| CN-112313335-B | Renin (AGT) iRNA compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2024-07-09 | — | — | CN | disclosed |
| CN-118302525-A | Complement Factor B (CFB) iRNA compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2024-07-05 | — | — | CN | disclosed |
| CN-118265786-A | Microtubule-associated protein Tau (MAPT) iRNA pharmaceutical compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2024-06-28 | — | — | CN | disclosed |
| CN-118251489-A | Regulation of gene transcription using antisense oligonucleotides targeted to regulatory RNAs | 4阵营疗法公司 | 2024-06-25 | — | — | CN | disclosed |
| CN-118217402-A | Combination therapy for C3 inhibition | 阿佩利斯制药有限公司 | 2024-06-21 | — | — | CN | disclosed |
| CN-118215735-A | APP iRNA compositions for treating or preventing diseases characterized by enlarged endosomes and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2024-06-18 | — | — | CN | disclosed |
| CN-118176300-A | Huntington (HTT) iRNA agent compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2024-06-11 | — | — | CN | disclosed |
| CN-118079015-A | Methods and compositions for treating proprotein convertase subtilisin KEXIN (PCSK 9) gene-related disorders | 阿尔尼拉姆医药品有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-118076361-A | Cell death-inducing DFFA-like effector B (CIDEB) iRNA compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2024-05-24 | — | — | CN | disclosed |
| CN-110272901-B | SERPINC1 iRNA compositions and methods of use thereof | 基酶有限公司 | 2023-08-04 | — | — | CN | disclosed |
| CN-116529372-A | Coagulation factor V (F5) iRNA compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2023-08-01 | — | — | CN | disclosed |
| CN-116234585-A | Microtubule-associated protein TAU (MAPT) iRNA agent compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2023-06-06 | — | — | CN | disclosed |
| CN-116209760-A | Xanthine Dehydrogenase (XDH) iRNA compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2023-06-02 | — | — | CN | disclosed |
| CN-116209759-A | Coronavirus iRNA compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2023-06-02 | — | — | CN | disclosed |
| CN-116096381-A | Complement Factor B (CFB) iRNA compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2023-05-09 | — | — | CN | disclosed |
| CN-116075592-A | SIRNA compositions and methods for silencing GPAM (mitochondrial glycerol-3-phosphate acyltransferase 1) expression | 阿尔尼拉姆医药品有限公司 | 2023-05-05 | — | — | CN | disclosed |
| CN-116064515-A | Transthyretin (TTR) iRNA compositions and methods of use thereof for treating or preventing TTR-related disorders | 阿尔尼拉姆医药品有限公司 | 2023-05-05 | — | — | CN | disclosed |
| CN-115298312-A | Leucine-rich repeat kinase 2 (LRRK 2) iRNA agent compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2022-11-04 | — | — | CN | disclosed |
| CN-114728018-A | Huntington (HTT) iRNA pharmaceutical compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2022-07-08 | — | — | CN | disclosed |