Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ADH5 | P11766 | 5/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28809740 | 0.77 | NOTUM (0.44) | MEN1KMT2ALMNAALDH1A1MAPK1 | |
| SCHEMBL14062140 | 0.75 | CYP11B1 (0.52) | CYP3A4CYP1A2CYP2D6CYP11B1CYP11B2 | |
| SCHEMBL5924613 | 0.74 | CYP2A6 (0.56) | LMNATP53ALDH1A1HPGDTSHR | |
| SCHEMBL1528608 | 0.71 | CYP3A4 (0.44) | CYP3A4MEN1KMT2ALMNAALOX15 | |
| SCHEMBL27943394 | 0.69 | NPC1 (0.51) | CYP3A4CYP1A2CYP2C19MEN1TP53 | |
| SCHEMBL14060078 | 0.69 | MEN1 (0.43) | CYP3A4CYP1A2CYP2D6CYP2C19MEN1 | |
| SCHEMBL14059902 | 0.69 | CYP1A2 (0.47) | CYP3A4CYP1A2CYP2D6CYP2C19LMNA | |
| SCHEMBL27953793 | 0.69 | CNR2 (0.52) | MEN1KMT2ALMNATP53HSD17B10 | |
| SCHEMBL27818233 | 0.68 | CYP11B1 (0.59) | CYP3A4CYP1A2CYP2D6CYP2C19LMNA | |
| SCHEMBL14060873 | 0.67 | AR (0.38) | LMNAALDH1A1NOTUMCYP2A6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103703005-A | Tricyclic inhibitors of kinases | ABBOTT LAB | 2014-04-02 | — | — | CN | claimed |
| CN-103703005-A | Tricyclic inhibitors of kinases | ABBOTT LAB | 2014-04-02 | — | — | CN | disclosed |