Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 3/20 | 0.40 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | LGMN | Q99538 | 1/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14060017 | 0.86 | ALDH1A1 (0.40) | CNR2CYP2A6PIK3C3LMNAALDH1A1 | |
| SCHEMBL27953793 | 0.83 | CNR2 (0.52) | MEN1KMT2ACNR2PIK3C3LMNA | |
| SCHEMBL14059902 | 0.83 | CYP1A2 (0.47) | CNR2PIK3C3LMNACYP1A2CYP2C19 | |
| SCHEMBL14060873 | 0.81 | AR (0.38) | CNR2CYP2A6PIK3C3LMNAALDH1A1 | |
| SCHEMBL5924613 | 0.75 | CYP2A6 (0.56) | CYP2A6LMNAALDH1A1TSHR | |
| SCHEMBL27943401 | 0.72 | HRH3 (0.41) | CNR2POLB | |
| SCHEMBL28809740 | 0.69 | NOTUM (0.44) | MEN1KMT2ACYP2A6LMNAALDH1A1 | |
| SCHEMBL28810623 | 0.69 | CYP3A4 (0.47) | MEN1KMT2ACYP2A6LMNACYP1A2 | |
| SCHEMBL27943380 | 0.68 | CNR2 (0.50) | MEN1KMT2ACNR2CYP2A13PIK3C3 | |
| SCHEMBL27943408 | 0.68 | DRD2 (0.45) | CYP1A2CYP2C19ALDH1A1CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103703005-A | Tricyclic inhibitors of kinases | ABBOTT LAB | 2014-04-02 | — | — | CN | claimed |
| CN-103703005-A | Tricyclic inhibitors of kinases | ABBOTT LAB | 2014-04-02 | — | — | CN | disclosed |
| EP-2681221-A1 | TRICYCLIC INHIBITORS OF KINASES | AbbVie Inc. (US) | 2014-01-08 | — | — | EP | disclosed |
| WO-2012161812-A1 | TRICYCLIC INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2012-11-29 | — | — | WO | disclosed |