Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.40 |
| ▸ | MAOB | P27338 | 4/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 2/20 | 0.33 |
| ▸ | DRD5 | P21918 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29843380 | 1.00 | MAOA (0.40) | MAOAMAOBSLC6A4ADRA2AADRA2B | |
| SCHEMBL25840894 | 0.79 | MAOA (0.40) | MAOAMAOBSLC6A4ADRA2AADRA2B | |
| SCHEMBL8185029 | 0.79 | MAOA (0.40) | MAOAMAOBSLC6A4KDM4EMAPT | |
| SCHEMBL24040089 | 0.79 | MAOA (0.40) | MAOAMAOBSLC6A4ADRA2AADRA2B | |
| SCHEMBL29557955 | 0.79 | MAOA (0.40) | MAOAMAOBSLC6A4ADRA2AADRA2B | |
| SCHEMBL8176774 | 0.73 | GRIA1 (0.49) | MAOAMAOBMAPTALDH1A1 | |
| SCHEMBL16076617 | 0.71 | MAOA (0.57) | MAOAMAOBADRA2AADRA2BADRA2C | |
| SCHEMBL22450600 | 0.71 | MAOA (0.55) | MAOAMAOBSLC6A4ADRA2AADRA2B | |
| SCHEMBL29507157 | 0.70 | MAOA (0.41) | MAOAMAOBSLC6A4ADRA2AADRA2B | |
| SCHEMBL22858691 | 0.70 | MAOA (0.41) | MAOAMAOBSLC6A4ADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114853730-B | Compounds used as HPK1 kinase inhibitor, preparation method and application thereof | 中国药科大学 | 2024-03-26 | — | — | CN | disclosed |
| CN-114853730-A | Compound used as HPK1 kinase inhibitor and preparation method and application thereof | 中国药科大学 | 2022-08-05 | — | — | CN | disclosed |