Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.40 |
| ▸ | RET | P07949 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 2/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27227964 | 0.86 | GAA (0.44) | GAACYP4F2CYP4A11RETALDH1A1 | |
| SCHEMBL30861031 | 0.86 | GAA (0.44) | GAACYP4F2CYP4A11RETALDH1A1 | |
| SCHEMBL30950290 | 0.86 | CYP4F2 (0.41) | GAACYP4F2CYP4A11RETMAP3K5 | |
| SCHEMBL29950914 | 0.84 | GAA (0.40) | GAACYP4F2CYP4A11RETALDH1A1 | |
| SCHEMBL14722738 | 0.84 | GAA (0.40) | GAACYP4F2CYP4A11RETALDH1A1 | |
| SCHEMBL31093784 | 0.84 | GAA (0.42) | GAACYP4F2CYP4A11RETALDH1A1 | |
| SCHEMBL14723565 | 0.83 | GAA (0.41) | GAACYP4F2CYP4A11RETALDH1A1 | |
| SCHEMBL27227929 | 0.81 | RXRA (0.38) | GAACYP4F2CYP4A11ALDH1A1HSD17B10 | |
| SCHEMBL24373243 | 0.81 | GAA (0.41) | GAACYP4F2CYP4A11RETALDH1A1 | |
| SCHEMBL31105919 | 0.81 | GAA (0.47) | GAACYP4F2CYP4A11RETALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117720533-A | MetTL3 inhibitor compound and pharmaceutical composition and application thereof | 北京华益健康药物研究中心 | 2024-03-19 | — | — | CN | disclosed |
| CN-114599651-A | Indazoles as inhibitors of hematopoietic progenitor kinase 1(HPK1) and methods of use thereof | 第一生物治疗股份有限公司 | 2022-06-07 | — | — | CN | disclosed |
| CN-114599653-A | Indazoles as inhibitors of hematopoietic progenitor kinase 1(HPK1) and methods of use thereof | 第一生物治疗股份有限公司 | 2022-06-07 | — | — | CN | disclosed |