Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 17/20 | 0.57 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.55 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7856894 | 1.00 | GABRA5 (0.57) | GABRA5GABRA1ITGA5 | |
| SCHEMBL288662 | 0.91 | GABRA5 (0.68) | GABRA5GABRA1ITGA5 | |
| SCHEMBL287943 | 0.86 | GABRA5 (0.71) | GABRA5GABRA1ITGA5 | |
| SCHEMBL286631 | 0.85 | GABRA5 (0.54) | GABRA5GABRA1ITGA5 | |
| SCHEMBL289211 | 0.85 | GABRA5 (0.57) | GABRA5GABRA1ITGA5 | |
| SCHEMBL298861 | 0.84 | GABRA5 (0.55) | GABRA5GABRA1ITGA5 | |
| SCHEMBL288080 | 0.84 | GABRA5 (0.55) | GABRA5GABRA1ITGA5 | |
| SCHEMBL288771 | 0.84 | GABRA5 (0.55) | GABRA5GABRA1ITGA5 | |
| SCHEMBL287977 | 0.83 | GABRA5 (0.55) | GABRA5GABRA1ITGA5 | |
| SCHEMBL288200 | 0.82 | GABRA5 (0.66) | GABRA5ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427456-A1 | ISOXAZOLE-PYRIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | disclosed |