Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 9/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.34 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16263673 | 0.86 | AAK1 (0.41) | LIPELMNAPOLBRXFP1AAK1 | |
| SCHEMBL29984550 | 0.86 | AAK1 (0.41) | LIPELMNAPOLBRXFP1AAK1 | |
| SCHEMBL14560 | 0.85 | LIPE (0.48) | LIPELMNAPOLBRXFP1AAK1 | |
| SCHEMBL3712015 | 0.84 | AAK1 (0.42) | LIPELMNAPOLBRXFP1AAK1 | |
| SCHEMBL24497673 | 0.82 | AAK1 (0.41) | LIPELMNAPOLBRXFP1AAK1 | |
| SCHEMBL30695853 | 0.80 | AAK1 (0.39) | LIPELMNAPOLBRXFP1AAK1 | |
| SCHEMBL1057040 | 0.79 | LIPE (0.46) | LIPELMNAPOLBRXFP1AAK1 | |
| SCHEMBL31534338 | 0.79 | AAK1 (0.36) | LIPELMNAPOLBRXFP1AAK1 | |
| SCHEMBL23564449 | 0.79 | AAK1 (0.41) | LIPELMNAPOLBRXFP1AAK1 | |
| SCHEMBL6652035 | 0.78 | AAK1 (0.42) | LIPELMNAPOLBRXFP1AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114853730-B | Compounds used as HPK1 kinase inhibitor, preparation method and application thereof | 中国药科大学 | 2024-03-26 | — | — | CN | disclosed |
| CN-114853730-A | Compound used as HPK1 kinase inhibitor and preparation method and application thereof | 中国药科大学 | 2022-08-05 | — | — | CN | disclosed |