Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | PLG | P00747 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27976688 | 0.88 | HDAC8 (0.56) | HDAC6HDAC8HDAC11HDAC3HDAC1 | |
| SCHEMBL27976655 | 0.87 | HDAC6 (0.58) | HDAC6HDAC8HDAC11HDAC3HDAC1 | |
| SCHEMBL27977005 | 0.87 | SCN9A (0.56) | HDAC6HDAC8HDAC11HDAC3HDAC1 | |
| SCHEMBL27976665 | 0.87 | HDAC8 (0.55) | HDAC6HDAC8HDAC11HDAC3HDAC1 | |
| SCHEMBL27976937 | 0.86 | HDAC8 (0.57) | HDAC6HDAC8HDAC11HDAC3HDAC1 | |
| SCHEMBL27976942 | 0.86 | PDE5A (0.59) | HDAC6HDAC8HDAC11HDAC3HDAC1 | |
| SCHEMBL27976649 | 0.86 | HDAC6 (0.54) | HDAC6HDAC8HDAC11HDAC3HDAC1 | |
| SCHEMBL27976621 | 0.85 | HDAC6 (0.53) | HDAC6HDAC8HDAC11HDAC3HDAC1 | |
| SCHEMBL27976653 | 0.84 | HDAC6 (0.55) | HDAC6HDAC8HDAC11HDAC3HDAC1 | |
| SCHEMBL27976977 | 0.84 | PLAU (0.47) | HDAC6HDAC8HDAC11HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104130175-A | Different-position substituted indolone derivatives and application thereof | UNIV TIANJIN SCIENCE & TECH | 2014-11-05 | — | — | CN | claimed |
| CN-104130175-A | Different-position substituted indolone derivatives and application thereof | UNIV TIANJIN SCIENCE & TECH | 2014-11-05 | — | — | CN | disclosed |