Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.55 |
| ▸ | MET | P08581 | 2/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5894379 | 0.89 | HDAC8 (0.56) | SCN9AHDAC8HDAC6HDAC11MET | |
| SCHEMBL27976688 | 0.88 | HDAC8 (0.56) | HDAC8HDAC6HDAC11HDAC3HDAC1 | |
| SCHEMBL27976655 | 0.87 | HDAC6 (0.58) | HDAC8HDAC6HDAC11HDAC3HDAC1 | |
| SCHEMBL28813667 | 0.87 | HDAC6 (0.55) | HDAC8HDAC6HDAC11HDAC3HDAC1 | |
| SCHEMBL27976937 | 0.86 | HDAC8 (0.57) | HDAC8HDAC6HDAC11HDAC3HDAC1 | |
| SCHEMBL4939166 | 0.86 | SCN9A (0.50) | SCN9AHDAC8HDAC6HDAC11MET | |
| SCHEMBL27976942 | 0.86 | PDE5A (0.59) | HDAC8HDAC6HDAC11HDAC3HDAC1 | |
| SCHEMBL27976649 | 0.86 | HDAC6 (0.54) | SCN9AHDAC8HDAC6HDAC11HDAC3 | |
| SCHEMBL4943532 | 0.85 | HTR6 (0.52) | SCN9AHDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL27976621 | 0.85 | HDAC6 (0.53) | HDAC8HDAC6HDAC11HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104130175-A | Different-position substituted indolone derivatives and application thereof | UNIV TIANJIN SCIENCE & TECH | 2014-11-05 | — | — | CN | claimed |
| CN-104130175-A | Different-position substituted indolone derivatives and application thereof | UNIV TIANJIN SCIENCE & TECH | 2014-11-05 | — | — | CN | disclosed |