Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27980042 | 0.85 | ALDH1A1 (0.36) | GAAPKMKMT2ALMNAMEN1 | |
| SCHEMBL28813927 | 0.82 | CTPS1 (0.33) | GAAPKMKMT2AMEN1POLB | |
| SCHEMBL14801332 | 0.82 | PIM1 (0.35) | KMT2ALMNAMEN1ALDH1A1MAPT | |
| SCHEMBL2515867 | 0.81 | MEN1 (0.39) | GAAPKMKMT2ALMNAMEN1 | |
| SCHEMBL2515869 | 0.81 | MEN1 (0.39) | GAAPKMKMT2ALMNAMEN1 | |
| SCHEMBL2522631 | 0.81 | MEN1 (0.39) | GAAPKMKMT2ALMNAMEN1 | |
| SCHEMBL27980071 | 0.81 | GAA (0.34) | GAAPKMKMT2AMEN1ALDH1A1 | |
| SCHEMBL28813851 | 0.79 | GAA (0.35) | GAAPKMKMT2AMEN1POLB | |
| SCHEMBL14686310 | 0.79 | KMT2A (0.42) | GAAPKMKMT2ALMNAMEN1 | |
| SCHEMBL14800963 | 0.77 | MEN1 (0.43) | GAAPKMKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103987707-A | Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use | HOFFMANN LA ROCHE | 2014-08-13 | — | — | CN | disclosed |