Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 6/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27983193 | 0.79 | DHFR (0.39) | PIK3CAPIK3CDPIK3CGPIK3C3PI4KB | |
| SCHEMBL4457723 | 0.76 | HCAR2 (0.43) | PIK3CADHFRADORA2AADORA1 | |
| SCHEMBL30065933 | 0.75 | NPC1 (0.50) | PIK3CADHFRFGFR1SRC | |
| SCHEMBL3663141 | 0.75 | NPC1 (0.50) | PIK3CADHFRFGFR1SRC | |
| SCHEMBL28664537 | 0.74 | MKNK1 (0.40) | PIK3CADHFRADORA2AADORA1 | |
| SCHEMBL27983086 | 0.70 | MKNK1 (0.34) | PIK3CAPIK3CDPIK3CGPIK3C3PI4KB | |
| SCHEMBL28814284 | 0.69 | PIK3CA (0.35) | PIK3CADHFRADORA2AADORA1 | |
| SCHEMBL27983380 | 0.69 | PIK3CA (0.35) | PIK3CADHFRADORA2AADORA1 | |
| SCHEMBL27983385 | 0.69 | PIK3CA (0.35) | PIK3CADHFRADORA2AADORA1 | |
| SCHEMBL28649163 | 0.69 | PIK3CA (0.40) | PIK3CADHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104024248-A | SERINE/THREONINE PAK1 INHIBITORS | HOFFMANN LA ROCHE | 2014-09-03 | — | — | CN | disclosed |