Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.66 |
| ▸ | TSHR | P16473 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | HPGD | P15428 | 5/20 | 0.58 |
| ▸ | HTT | P42858 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | PDE6D | O43924 | 2/20 | 0.50 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.50 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28815849 | 0.85 | HSD17B10 (0.74) | HSD17B10TSHRLMNAKDM4EALDH1A1 | |
| SCHEMBL15474489 | 0.84 | KDM4E (0.72) | HSD17B10TSHRLMNAKDM4EALDH1A1 | |
| SCHEMBL30410670 | 0.80 | HSD17B10 (1.00) | HSD17B10TSHRLMNAKDM4EALDH1A1 | |
| SCHEMBL25454233 | 0.80 | HSD17B10 (1.00) | HSD17B10TSHRLMNAKDM4EALDH1A1 | |
| SCHEMBL15643888 | 0.80 | HSD17B10 (1.00) | HSD17B10TSHRLMNAKDM4EALDH1A1 | |
| SCHEMBL22769595 | 0.78 | HSD17B10 (0.74) | HSD17B10TSHRLMNAKDM4EALDH1A1 | |
| SCHEMBL14397087 | 0.77 | KDM4E (0.78) | HSD17B10TSHRLMNAKDM4EALDH1A1 | |
| SCHEMBL18968584 | 0.77 | KDM4E (0.64) | HSD17B10TSHRLMNAKDM4EALDH1A1 | |
| SCHEMBL5884114 | 0.77 | HPGD (0.65) | HSD17B10TSHRLMNAKDM4EALDH1A1 | |
| SCHEMBL14646191 | 0.77 | HSD17B10 (0.94) | HSD17B10TSHRLMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114874229-B | 5, 6-dihydro-benzimidazol isoquinoline spiro lactone compound and synthetic method and application thereof | 杭州医学院 | 2023-07-18 | — | — | CN | disclosed |
| CN-114874229-A | 5, 6-dihydrobenzimidazoisoquinoline spiro lactone compound and synthesis method and application thereof | 杭州医学院 | 2022-08-09 | — | — | CN | disclosed |