Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | PDE6D | O43924 | 1/20 | 0.56 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.56 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22784030 | 0.91 | HSD17B10 (0.61) | HSD17B10KDM4ELMNATSHR | |
| SCHEMBL22784029 | 0.88 | KDM4E (0.57) | HSD17B10KDM4ELMNATSHRALDH1A1 | |
| SCHEMBL22769585 | 0.86 | KDM4E (0.62) | HSD17B10KDM4ELMNATSHRALDH1A1 | |
| SCHEMBL22776356 | 0.86 | ALDH1A1 (0.69) | HSD17B10KDM4ELMNATSHRALDH1A1 | |
| SCHEMBL15643888 | 0.85 | HSD17B10 (1.00) | HSD17B10KDM4ELMNATSHRALDH1A1 | |
| SCHEMBL22769586 | 0.84 | KDM4E (0.59) | HSD17B10KDM4ELMNATSHRALDH1A1 | |
| SCHEMBL2607350 | 0.83 | KDM4E (0.62) | HSD17B10KDM4ELMNAALDH1A1MEN1 | |
| SCHEMBL25143531 | 0.83 | RECQL (0.57) | HSD17B10KDM4ELMNATSHRALDH1A1 | |
| SCHEMBL14397087 | 0.82 | KDM4E (0.78) | HSD17B10KDM4ELMNATSHRALDH1A1 | |
| SCHEMBL22769611 | 0.82 | KMT2A (0.56) | HSD17B10KDM4ELMNATSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250388544-A1 | HETEROAROMATIC INHIBITORS OF ASTACIN PROTEINASES | VIVORYON THERAPEUTICS N.V. (DE) | 2025-12-25 | — | — | US | disclosed |
| EP-3750878-B1 | HETEROAROMATIC INHIBITORS OF ASTACIN PROTEINASES | VIVORYON THERAPEUTICS N V (DE) | 2025-05-14 | — | — | EP | disclosed |
| US-20230122243-A1 | Heteroaromatic inhibitors of astacin proteinases | VIVORYON THERAPEUTICS N.V. (DE) | 2023-04-20 | — | — | US | disclosed |
| US-20230122243-A1 | Heteroaromatic inhibitors of astacin proteinases | VIVORYON THERAPEUTICS N.V. (DE) | 2023-04-20 | — | — | US | disclosed |
| CN-114585608-A | Heteroaromatic inhibitors of astacin protease | 维沃永治疗公众有限公司 | 2022-06-03 | — | — | CN | disclosed |
| EP-3986868-A1 | HETEROAROMATIC INHIBITORS OF ASTACIN PROTEINASES | Vivoryon Therapeutics N.V. (DE) | 2022-04-27 | — | — | EP | disclosed |
| WO-2020249760-A1 | HETEROAROMATIC INHIBITORS OF ASTACIN PROTEINASES | VIVORYON THERAPEUTICS AG (DE) | 2020-12-17 | — | — | WO | disclosed |
| WO-2020249760-A1 | HETEROAROMATIC INHIBITORS OF ASTACIN PROTEINASES | VIVORYON THERAPEUTICS AG (DE) | 2020-12-17 | — | — | WO | disclosed |
| EP-3750878-A1 | HETEROAROMATIC INHIBITORS OF ASTACIN PROTEINASES | Vivoryon Therapeutics AG (DE) | 2020-12-16 | — | — | EP | disclosed |
| EP-3750878-A1 | HETEROAROMATIC INHIBITORS OF ASTACIN PROTEINASES | Vivoryon Therapeutics AG (DE) | 2020-12-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230122243-A1 | Heteroaromatic inhibitors of astacin proteinases | BMP1, DPEP1, MEP1A | HSD17B10 2223/4885KDM4E 2174/4885LMNA 2719/4885 |
| US-20250388544-A1 | HETEROAROMATIC INHIBITORS OF ASTACIN PROTEINASES | BMP1, BMPR1A, BMPR1B | HSD17B10 1260/4885KDM4E 2946/4885LMNA 946/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.