Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | GRM8 | O00222 | 1/20 | 0.34 |
| ▸ | GRM6 | O15303 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GSR | P00390 | 1/20 | 0.34 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL972770 | 1.00 | KMT2A (0.52) | KMT2AALOX15BLMPMP22DPP4 | |
| SCHEMBL711607 | 0.87 | ALOX15 (0.60) | KMT2AALOX15BLMPMP22DPP4 | |
| SCHEMBL28313344 | 0.87 | ALOX15 (0.60) | KMT2AALOX15BLMPMP22DPP4 | |
| SCHEMBL1237866 | 0.85 | ALOX15 (0.48) | KMT2AALOX15BLMPMP22DPP4 | |
| SCHEMBL23200441 | 0.84 | CYP1A2 (0.54) | KMT2AALOX15BLMPMP22DPP4 | |
| SCHEMBL1606668 | 0.84 | SLC1A1 (0.36) | KMT2AALOX15BLMPMP22ALDH1A1 | |
| SCHEMBL8838342 | 0.84 | CYP1A2 (0.54) | KMT2AALOX15BLMPMP22DPP4 | |
| SCHEMBL8128271 | 0.84 | SLC1A1 (0.36) | KMT2AALOX15BLMPMP22ALDH1A1 | |
| SCHEMBL8838340 | 0.84 | SLC1A1 (0.36) | KMT2AALOX15BLMPMP22ALDH1A1 | |
| SCHEMBL7176759 | 0.83 | ALOX15 (0.56) | KMT2AALOX15BLMPMP22DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114945369-A | Methods of treating HER2 positive breast cancer with a combination of Tucotinib and an anti-HER 2 antibody-drug conjugate | 思进公司 | 2022-08-26 | — | — | CN | disclosed |