Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10900780 | 0.81 | LMNA (0.49) | LMNATSHRF2CES2CES1 | |
| SCHEMBL15375452 | 0.78 | LMNA (0.46) | LMNATSHRF2CES2CES1 | |
| SCHEMBL29076152 | 0.76 | LMNA (0.47) | LMNATSHRF2CES2CES1 | |
| SCHEMBL9183020 | 0.75 | TDP1 (0.48) | LMNATSHRF2CES2CES1 | |
| SCHEMBL4577714 | 0.75 | LMNA (0.46) | LMNATSHRF2CES2CES1 | |
| SCHEMBL29788769 | 0.74 | LMNA (0.67) | LMNATSHRF2CES2CES1 | |
| SCHEMBL5799668 | 0.74 | TSHR (0.52) | LMNATSHRF2CES2CES1 | |
| SCHEMBL5799667 | 0.74 | TSHR (0.52) | LMNATSHRF2CES2CES1 | |
| SCHEMBL242716 | 0.74 | LMNA (0.57) | LMNATSHRF2CES2CES1 | |
| Formic Acid SCHEMBL27875019 | 0.73 | LMNA (0.58) | LMNATSHRF2CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114901653-A | Novel amide derivatives useful as diacylglycerol acyltransferase 2 inhibitors and uses thereof | 株式会社LG化学 | 2022-08-12 | — | — | CN | disclosed |