Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Phenanthroline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.58 |
| ▸ | CCR1 | P32246 | 5/20 | 0.94 |
| ▸ | CCR8 | P51685 | 5/20 | 0.94 |
| ▸ | LMNA | P02545 | 4/20 | 0.94 |
| ▸ | CCR5 | P51681 | 3/20 | 0.94 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.94 |
| ▸ | MMP2 | P08253 | 2/20 | 0.94 |
| ▸ | TSHR | P16473 | 2/20 | 0.94 |
| ▸ | MAPT | P10636 | 2/20 | 0.94 |
| ▸ | HTT | P42858 | 2/20 | 0.94 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.94 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.94 |
| ▸ | GMNN | O75496 | 1/20 | 0.94 |
| ▸ | TP53 | P04637 | 1/20 | 0.94 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.94 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.94 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.94 |
| ▸ | MMP9 | P14780 | 1/20 | 0.94 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.94 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.94 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenanthroline SCHEMBL31515786 | 1.00 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL10729466 | 1.00 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL10729481 | 1.00 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL28417620 | 0.97 | CCR1 (0.89) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL29354015 | 0.97 | CCR1 (1.00) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL29367277 | 0.97 | CCR1 (1.00) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL8845760 | 0.97 | CCR1 (1.00) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL8312 | 0.97 | CCR1 (1.00) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL22982126 | 0.94 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL22462277 | 0.94 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115636890-A | Iron catalyst for selective polymerization of conjugated diolefins with 1,2/3,4 and application thereof | 宁波大学 | 2023-01-24 | — | — | CN | disclosed |
| US-7847126-B2 | prepared by reacting phosphorus halide with organomagnesium compound in presence of copper compound; di(tert-butyl)phenylphosphonium tetrafluoroborate, for example | LANXESS DEUTSCHLAND GMBH (DE) | 2010-12-07 | — | — | US | disclosed |
| US-20030229240-A1 | Reacting phosphorus halide with organomagnesium compound in presence of copper compound | LANXESS DEUTSCHLAND GMBH (DE) | 2003-12-11 | — | — | US | disclosed |