Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.37 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7618304 | 0.94 | POLB (0.41) | LMNACYP3A4GABRA1TSHRGABRG2 | |
| SCHEMBL342435 | 0.91 | POLB (0.42) | LMNACYP3A4GABRA1TSHRGABRG2 | |
| SCHEMBL10823165 | 0.89 | POLB (0.41) | LMNACYP3A4GABRA1TSHRGABRG2 | |
| SCHEMBL63679 | 0.89 | PTGS1 (0.39) | LMNAPOLBPTGS1PDE4ASLC6A6 | |
| SCHEMBL789961 | 0.89 | PTGS1 (0.39) | LMNAPOLBPTGS1PDE4ASLC6A6 | |
| SCHEMBL14414885 | 0.89 | PTGS1 (0.39) | LMNAPOLBPTGS1PDE4ASLC6A6 | |
| SCHEMBL2403909 | 0.89 | — | — | |
| Water SCHEMBL28459309 | 0.88 | POLB (0.39) | LMNACYP3A4GABRA1TSHRGABRG2 | |
| Potassium Ion SCHEMBL28852047 | 0.88 | POLB (0.39) | LMNACYP3A4GABRA1TSHRGABRG2 | |
| SCHEMBL2511955 | 0.87 | ALDH1A1 (0.37) | LMNACYP3A4GABRA1TSHRGABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104792718-A | Serum gamma-glutamyl transferase reagent and detection method thereof | BIOBASE BIODUSTRY SHANDONG CO | 2015-07-22 | — | — | CN | disclosed |