Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Px-102. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 known ✓ | Q96RI1 | 20/20 | 0.91 |
| ▸ | FXR2 | P51116 | 1/20 | 0.91 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Px-102 SCHEMBL12098287 | 1.00 | NR1H4 (0.91) | NR1H4FXR2 | |
| Px-102 SCHEMBL19633868 | 0.95 | NR1H4 (1.00) | NR1H4FXR2 | |
| Px-102 SCHEMBL29823470 | 0.95 | NR1H4 (1.00) | NR1H4FXR2 | |
| Px-102 SCHEMBL29366746 | 0.95 | NR1H4 (1.00) | NR1H4FXR2 | |
| Px-102 SCHEMBL17087856 | 0.95 | NR1H4 (1.00) | NR1H4FXR2 | |
| Px-102 SCHEMBL24662891 | 0.95 | NR1H4 (1.00) | NR1H4FXR2 | |
| Px-102 SCHEMBL17087854 | 0.95 | NR1H4 (1.00) | NR1H4FXR2 | |
| Px-102 SCHEMBL17087850 | 0.95 | NR1H4 (1.00) | NR1H4FXR2 | |
| Px-102 SCHEMBL29709582 | 0.95 | NR1H4 (1.00) | NR1H4FXR2 | |
| Px-102 SCHEMBL17087855 | 0.95 | NR1H4 (1.00) | NR1H4FXR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110404073-B | Methods and pharmaceutical compositions for treating hepatitis B virus infection | 国家医疗保健研究所 | 2022-08-16 | — | — | CN | disclosed |