Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 1/20 | 0.50 |
| ▸ | BRAF | P15056 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 10/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | FBP1 | P09467 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.47 |
| ▸ | TEK | Q02763 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29881898 | 1.00 | RAF1 (0.50) | RAF1BRAFAPPEGFRERBB2 | |
| SCHEMBL27896795 | 0.85 | EGFR (0.51) | APPEGFRERBB2KDRAURKA | |
| SCHEMBL28820802 | 0.84 | EGFR (0.50) | EGFRERBB2KDRAURKAINSR | |
| SCHEMBL29881841 | 0.84 | EGFR (0.50) | EGFRERBB2KDRAURKAINSR | |
| SCHEMBL29881732 | 0.81 | EGFR (0.55) | EGFRERBB2KDRAURKAINSR | |
| SCHEMBL28820840 | 0.81 | EGFR (0.55) | EGFRERBB2KDRAURKAINSR | |
| SCHEMBL28820798 | 0.81 | MAPT (0.44) | BRAFPDGFRBMAPTPOLBKDM4E | |
| SCHEMBL29882028 | 0.78 | EGFR (0.67) | EGFRKDRCSF1R | |
| SCHEMBL29882009 | 0.78 | EGFR (0.67) | EGFRERBB2KDRAURKAINSR | |
| SCHEMBL30602465 | 0.77 | EGFR (0.51) | RAF1BRAFAPPEGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114907261-B | 2-phenylaminoquinoline derivative, preparation method and application thereof | 湖南中医药大学 | 2023-10-27 | — | — | CN | disclosed |
| CN-114907261-A | 2-phenylamino quinoline derivative and preparation method and application thereof | 湖南中医药大学 | 2022-08-16 | — | — | CN | disclosed |