Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.48 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | INSR | P06213 | 1/20 | 0.48 |
| ▸ | FBP1 | P09467 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | FLT4 | P35916 | 1/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.48 |
| ▸ | TEK | Q02763 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29881841 | 1.00 | EGFR (0.50) | EGFRCSF1RERBB2KDRAURKA | |
| SCHEMBL27896795 | 0.85 | EGFR (0.51) | EGFRCSF1RERBB2KDRAURKA | |
| SCHEMBL30968993 | 0.84 | EGFR (0.53) | EGFRCSF1RERBB2KDRAURKA | |
| SCHEMBL28820741 | 0.84 | RAF1 (0.50) | EGFRCSF1RERBB2KDRAURKA | |
| SCHEMBL29881898 | 0.84 | RAF1 (0.50) | EGFRCSF1RERBB2KDRAURKA | |
| SCHEMBL28820762 | 0.82 | SLC2A1 (0.44) | EGFRKDRPDGFRBMAPTPOLB | |
| SCHEMBL28820840 | 0.81 | EGFR (0.55) | EGFRERBB2KDRAURKAINSR | |
| SCHEMBL29881732 | 0.81 | EGFR (0.55) | EGFRERBB2KDRAURKAINSR | |
| SCHEMBL29882028 | 0.78 | EGFR (0.67) | EGFRCSF1RKDR | |
| SCHEMBL30968994 | 0.78 | EGFR (0.82) | EGFRERBB2KDRAURKAINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114907261-B | 2-phenylaminoquinoline derivative, preparation method and application thereof | 湖南中医药大学 | 2023-10-27 | — | — | CN | disclosed |
| CN-114907261-A | 2-phenylamino quinoline derivative and preparation method and application thereof | 湖南中医药大学 | 2022-08-16 | — | — | CN | disclosed |