Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 5/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.62 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 3/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | YWHAG | P61981 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23410173 | 0.94 | TGFBR1 (0.60) | TGFBR1MAPK14GPR139HTTCNR1 | |
| SCHEMBL28822071 | 0.93 | TGFBR1 (0.69) | TGFBR1MAPK14CNR1ALDH1A1LMNA | |
| SCHEMBL28822077 | 0.91 | TGFBR1 (0.59) | TGFBR1MAPK14CNR1ENPP2LMNA | |
| SCHEMBL29959820 | 0.91 | TGFBR1 (0.59) | TGFBR1MAPK14ENPP2PKMLMNA | |
| SCHEMBL23409664 | 0.91 | TGFBR1 (0.59) | TGFBR1MAPK14ENPP2PKMLMNA | |
| SCHEMBL23409951 | 0.91 | TGFBR1 (0.59) | TGFBR1MAPK14PKMALDH1A1LMNA | |
| SCHEMBL23409924 | 0.90 | TGFBR1 (0.61) | TGFBR1MAPK14GPR139CNR1KMT2A | |
| SCHEMBL29959785 | 0.90 | TGFBR1 (0.61) | TGFBR1MAPK14GPR139CNR1KMT2A | |
| SCHEMBL31519383 | 0.90 | TGFBR1 (0.61) | TGFBR1MAPK14PKMALDH1A1THRB | |
| Hydrochloric Acid SCHEMBL23409670 | 0.89 | TGFBR1 (0.60) | TGFBR1MAPK14PKMTHRBALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12297186-B2 | Benzylamide derivatives as inhibitors of transforming growth factor-beta receptor I/ALK5 | Agomab Spain, S.L.U. (ES) | 2025-05-13 | — | — | US | claimed |
| CN-114787145-B | Benzamide derivatives as transforming growth factor-beta receptor I/ALK5 inhibitors | 阿戈麦布西班牙股份有限公司 | 2024-03-26 | — | — | CN | claimed |
| US-20230025933-A1 | Benzylamide Derivatives as Inhibitors of Transforming Growth Factor-Beta Receptor I/Alk5 | Agomab Spain, S.L.U. (ES) | 2023-01-26 | — | — | US | claimed |
| EP-4065572-A1 | BENZYLAMIDE DERIVATIVES AS INHIBITORS OF TRANSFORMING GROWTH FACTOR-BETA RECEPTOR I/ALK5 | Origo Biopharma, S.L. (ES) | 2022-10-05 | — | — | EP | claimed |
| CN-114787145-A | Benzamide derivatives as transforming growth factor-beta receptor I/ALK5 inhibitors | 奥里戈生物制药有限公司 | 2022-07-22 | — | — | CN | claimed |
| CN-114787145-B | Benzamide derivatives as transforming growth factor-beta receptor I/ALK5 inhibitors | 阿戈麦布西班牙股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| EP-4065572-A1 | BENZYLAMIDE DERIVATIVES AS INHIBITORS OF TRANSFORMING GROWTH FACTOR-BETA RECEPTOR I/ALK5 | Origo Biopharma, S.L. (ES) | 2022-10-05 | — | — | EP | disclosed |
| CN-114787145-A | Benzamide derivatives as transforming growth factor-beta receptor I/ALK5 inhibitors | 奥里戈生物制药有限公司 | 2022-07-22 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12297186-B2 | Benzylamide derivatives as inhibitors of transforming growth factor-beta receptor I/ALK5 | TGFBR2, TGFBR1, ACVR1 | TGFBR1 2/4885MAPK14 1610/4885GPR139 372/4885 |
| US-20230025933-A1 | Benzylamide Derivatives as Inhibitors of Transforming Growth Factor-Beta Receptor I/Alk5 | TGFBR2, TGFBR1, ACVR1 | TGFBR1 2/4885MAPK14 1610/4885GPR139 372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.