Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 7/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 7/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 7/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | STAT6 | P42226 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | CD38 | P28907 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2149236 | 0.84 | CYSLTR1 (0.49) | CYP1A2CYP1A1CYP1B1CYP2D6DHODH | |
| SCHEMBL2529900 | 0.80 | CYP1A1 (0.43) | CYP1A2CYP1A1CYP1B1CYP2D6DHODH | |
| SCHEMBL9330744 | 0.79 | CYP1A2 (0.58) | CYP1A2CYP1A1CYP1B1CYP2D6GLA | |
| SCHEMBL28822757 | 0.78 | CYP3A4 (0.48) | CYP1A2CYP1A1CYP1B1CYP2D6DHODH | |
| SCHEMBL2148915 | 0.78 | KDM4E (0.43) | CYP1A2CYP1A1CYP1B1DHODHCYP3A4 | |
| SCHEMBL9329003 | 0.78 | CYP1A2 (0.48) | CYP1A2CYP1A1CYP1B1CYP2D6GLA | |
| SCHEMBL7082926 | 0.78 | CYP1A2 (0.59) | CYP1A2CYP1A1CYP1B1CYP2D6GLA | |
| SCHEMBL12835307 | 0.78 | CYP3A4 (0.60) | CYP1A2CYP1A1CYP1B1CYP2D6GLA | |
| SCHEMBL7086520 | 0.77 | CYP1A2 (0.55) | CYP1A2CYP1A1CYP1B1CYP2D6GLA | |
| SCHEMBL7085772 | 0.77 | CYP3A4 (0.48) | CYP1A2CYP1A1CYP1B1CYP2D6GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105198872-A | Chromenone analogs as sirtuin modulators | SIRTRIS PHARMACEUTICALS INC | 2015-12-30 | — | — | CN | disclosed |
| CN-102227417-B | Chromenone analogs as sirtuin modulators | SIRTRIS PHARMACEUTICALS, INC. (US) | 2015-09-16 | — | — | CN | disclosed |