Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 10/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 9/20 | 0.52 |
| ▸ | USP8 | P40818 | 1/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.50 |
| ▸ | DPP4 | P27487 | 1/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28822972 | 1.00 | KDM4E (0.53) | KDM4ELMNAGAAL3MBTL1ADORA1 | |
| SCHEMBL28823015 | 0.90 | USP8 (0.58) | KDM4ELMNAADORA1ADORA2AUSP8 | |
| SCHEMBL28949045 | 0.88 | ADORA1 (0.66) | ADORA1ADORA2AUSP8ADORA2BDPP4 | |
| SCHEMBL28823023 | 0.88 | ADORA1 (0.66) | ADORA1ADORA2AUSP8ADORA2BDPP4 | |
| SCHEMBL28822974 | 0.84 | ADORA1 (0.61) | KDM4ELMNAADORA1ADORA2AUSP8 | |
| SCHEMBL28823036 | 0.84 | ADORA1 (0.61) | KDM4EGAAADORA1ADORA2AUSP8 | |
| SCHEMBL28822973 | 0.84 | USP8 (0.57) | KDM4ELMNAL3MBTL1ADORA1ADORA2A | |
| SCHEMBL28822976 | 0.84 | USP8 (0.57) | KDM4ELMNAL3MBTL1ADORA1ADORA2A | |
| SCHEMBL20666626 | 0.83 | ADORA2A (0.62) | KDM4ELMNAL3MBTL1ADORA1ADORA2A | |
| SCHEMBL4678518 | 0.81 | ERBB2 (0.61) | KDM4ELMNAGAAL3MBTL1USP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114644597-B | Tetra-substituted pyrazine derivative and preparation method and application thereof | 南京农业大学 | 2023-11-21 | — | — | CN | claimed |
| CN-114644597-A | Tetra-substituted pyrazine derivative and preparation method and application thereof | 南京农业大学 | 2022-06-21 | — | — | CN | claimed |
| CN-114644597-B | Tetra-substituted pyrazine derivative and preparation method and application thereof | 南京农业大学 | 2023-11-21 | — | — | CN | disclosed |
| CN-114644597-A | Tetra-substituted pyrazine derivative and preparation method and application thereof | 南京农业大学 | 2022-06-21 | — | — | CN | disclosed |