Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 13/20 | 0.66 |
| ▸ | ADORA2A | P29274 | 13/20 | 0.66 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.66 |
| ▸ | DPP4 | P27487 | 1/20 | 0.50 |
| ▸ | USP8 | P40818 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28823023 | 1.00 | ADORA1 (0.66) | ADORA1ADORA2AADORA2BDPP4USP8 | |
| SCHEMBL28822972 | 0.88 | KDM4E (0.53) | ADORA1ADORA2AADORA2BDPP4USP8 | |
| SCHEMBL28822945 | 0.88 | KDM4E (0.53) | ADORA1ADORA2AADORA2BDPP4USP8 | |
| SCHEMBL28823015 | 0.87 | USP8 (0.58) | ADORA1ADORA2AADORA2BUSP8 | |
| SCHEMBL28822957 | 0.82 | ADORA1 (0.56) | ADORA1ADORA2AADORA2BDPP4USP8 | |
| SCHEMBL28822967 | 0.82 | ADORA1 (0.56) | ADORA1ADORA2AADORA2BDPP4USP8 | |
| SCHEMBL28822976 | 0.81 | USP8 (0.57) | ADORA1ADORA2AADORA2BDPP4USP8 | |
| SCHEMBL28822973 | 0.81 | USP8 (0.57) | ADORA1ADORA2AADORA2BDPP4USP8 | |
| SCHEMBL20667474 | 0.81 | ADORA2A (0.58) | ADORA1ADORA2AADORA2B | |
| SCHEMBL20666626 | 0.81 | ADORA2A (0.62) | ADORA1ADORA2AADORA2BUSP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114644597-B | Tetra-substituted pyrazine derivative and preparation method and application thereof | 南京农业大学 | 2023-11-21 | — | — | CN | claimed |
| CN-114644597-A | Tetra-substituted pyrazine derivative and preparation method and application thereof | 南京农业大学 | 2022-06-21 | — | — | CN | claimed |
| CN-114644597-B | Tetra-substituted pyrazine derivative and preparation method and application thereof | 南京农业大学 | 2023-11-21 | — | — | CN | disclosed |
| CN-114644597-A | Tetra-substituted pyrazine derivative and preparation method and application thereof | 南京农业大学 | 2022-06-21 | — | — | CN | disclosed |