Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP8 | P40818 | 3/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | GRK5 | P34947 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | PRKX | P51817 | 1/20 | 0.47 |
| ▸ | NEK2 | P51955 | 1/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.47 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.47 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28823041 | 1.00 | USP8 (0.57) | USP8CHEK1ABL1PDGFRBPDGFRA | |
| SCHEMBL28823015 | 0.86 | USP8 (0.58) | USP8CHEK1ABL1PDGFRBPDGFRA | |
| SCHEMBL28822973 | 0.83 | USP8 (0.57) | USP8DPP4LMNAADORA2AADORA1 | |
| SCHEMBL28822976 | 0.83 | USP8 (0.57) | USP8DPP4LMNAADORA2AADORA1 | |
| SCHEMBL28822957 | 0.81 | ADORA1 (0.56) | USP8CHEK1ABL1PDGFRBPDGFRA | |
| SCHEMBL28822967 | 0.81 | ADORA1 (0.56) | USP8CHEK1ABL1PDGFRBPDGFRA | |
| SCHEMBL11370778 | 0.80 | CHEK1 (0.53) | USP8CHEK1ABL1PDGFRBPDGFRA | |
| SCHEMBL11809427 | 0.80 | CHEK1 (0.53) | USP8CHEK1ABL1PDGFRBPDGFRA | |
| SCHEMBL28822974 | 0.78 | ADORA1 (0.61) | USP8CHEK1ABL1PDGFRBPDGFRA | |
| SCHEMBL28822945 | 0.78 | KDM4E (0.53) | USP8DPP4LMNAADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114644597-B | Tetra-substituted pyrazine derivative and preparation method and application thereof | 南京农业大学 | 2023-11-21 | — | — | CN | claimed |
| CN-114644597-A | Tetra-substituted pyrazine derivative and preparation method and application thereof | 南京农业大学 | 2022-06-21 | — | — | CN | claimed |
| CN-114644597-B | Tetra-substituted pyrazine derivative and preparation method and application thereof | 南京农业大学 | 2023-11-21 | — | — | CN | disclosed |
| CN-114644597-A | Tetra-substituted pyrazine derivative and preparation method and application thereof | 南京农业大学 | 2022-06-21 | — | — | CN | disclosed |