Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.47 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 3/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.32 |
| ▸ | FEN1 | P39748 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.31 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.31 |
| ▸ | PDE1A | P54750 | 1/20 | 0.31 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.31 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | RXRA | P19793 | 2/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22679340 | 0.86 | TRPV4 (0.50) | TRPV4LPAR1NR3C1PGRDRD1 | |
| SCHEMBL26463446 | 0.80 | TRPV4 (0.45) | TRPV4LPAR1NR3C1PGRSLC6A2 | |
| SCHEMBL26862267 | 0.77 | TRPV4 (0.40) | TRPV4LPAR1DRD1ALOX5APFEN1 | |
| SCHEMBL2646025 | 0.74 | TRPV4 (0.57) | TRPV4LPAR1NR3C1PGRDRD1 | |
| SCHEMBL21225855 | 0.74 | TRPV4 (0.53) | TRPV4NR3C1PGRTYK2RXRA | |
| SCHEMBL30277698 | 0.74 | TRPV4 (0.53) | TRPV4LPAR1NR3C1PGRDRD1 | |
| SCHEMBL31348088 | 0.74 | TRPV4 (0.53) | TRPV4NR3C1PGRTYK2RXRA | |
| SCHEMBL15951019 | 0.74 | TRPV4 (0.53) | TRPV4LPAR1NR3C1PGRDRD1 | |
| SCHEMBL23286944 | 0.74 | TRPV4 (0.49) | TRPV4LPAR1NR3C1PGRPDE1A | |
| SCHEMBL21222838 | 0.72 | TRPV4 (0.54) | TRPV4NR3C1PGRDRD1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143207-A | Substituted pyridine and substituted pyrazine compounds as PDE4 inhibitors | DART NEUROSCIENCE LLC | 2015-12-09 | — | — | CN | disclosed |