Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.35 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.35 |
| ▸ | ADRB3 known ✓ | P13945 | 1/20 | 0.35 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.35 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.35 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.35 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.35 |
| ▸ | TYR | P14679 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27813430 | 0.96 | TYR (0.47) | TYRKCNH2CYP3A4MAPTTP53 | |
| SCHEMBL1260062 | 0.89 | TYR (0.41) | TYRKCNH2CYP3A4MAPTTP53 | |
| SCHEMBL14868199 | 0.81 | PDE10A (0.41) | KDM4EALDH1A1GAAHPGDADORA2A | |
| SCHEMBL11728240 | 0.78 | KCNH2 (0.55) | TYRKCNH2CYP3A4MAPTTP53 | |
| SCHEMBL24609039 | 0.76 | TLR8 (0.53) | TYRTLR8 | |
| SCHEMBL22546299 | 0.76 | KCNH2 (0.53) | TYRKCNH2CYP3A4MAPTTP53 | |
| SCHEMBL19966840 | 0.75 | KCNH2 (0.43) | TYRKCNH2CYP3A4MAPTTP53 | |
| Bromide SCHEMBL29929790 | 0.74 | LIPG (0.46) | TYRKCNH2CYP3A4MAPTTP53 | |
| Bromide SCHEMBL27702663 | 0.74 | LIPG (0.46) | TYRKCNH2CYP3A4MAPTTP53 | |
| SCHEMBL11686108 | 0.73 | TYR (0.55) | TYRKCNH2CYP3A4MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999840-A | Nucleic acid sample preservation solution and use method and application thereof | 上海市刑事科学技术研究院 | 2022-02-01 | — | — | CN | claimed |