Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24367589 | 0.89 | NR1H2 (0.55) | NR1H2PDE4BRORCUSP2SMN1; SMN2 | |
| SCHEMBL5311614 | 0.84 | NR1H2 (0.54) | NR1H2PDE4BUSP2SMN1; SMN2GPR119 | |
| SCHEMBL37879 | 0.84 | NR1H2 (0.54) | NR1H2PDE4BUSP2SMN1; SMN2GPR119 | |
| SCHEMBL13987271 | 0.84 | GPR119 (0.53) | USP2SMN1; SMN2GPR119HPGDRECQL | |
| SCHEMBL7450072 | 0.84 | GPR119 (0.53) | USP2SMN1; SMN2GPR119HPGDRECQL | |
| SCHEMBL1052921 | 0.83 | NR1H2 (0.53) | NR1H2PDE4BRORCUSP2SMN1; SMN2 | |
| SCHEMBL6065186 | 0.83 | NR1H2 (0.53) | NR1H2PDE4BRORCUSP2SMN1; SMN2 | |
| SCHEMBL1051376 | 0.83 | NR1H2 (0.53) | NR1H2PDE4BRORCUSP2SMN1; SMN2 | |
| SCHEMBL24814108 | 0.82 | NR1H2 (0.48) | NR1H2PDE4BRORCUSP2SMN1; SMN2 | |
| SCHEMBL30278408 | 0.81 | NR1H2 (0.54) | NR1H2PDE4BRORCUSP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105315188-A | Preparation method of 2-(1-(tertbutyloxycarbonyl)azacyclobutyl-3-yl)cyclopropanecarboxylic acid | WUXI APPTEC CO LTD | 2016-02-10 | — | — | CN | disclosed |
| CN-105315188-A | Preparation method of 2-(1-(tertbutyloxycarbonyl)azacyclobutyl-3-yl)cyclopropanecarboxylic acid | WUXI APPTEC CO LTD | 2016-02-10 | — | — | CN | disclosed |